Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/21/21 11:45 AM | 12/21/21 11:45 AM | Vitesse Arnheim | PEC Zwolle | 1-0 | 2 - 4 points |
| 12/21/21 2:00 PM | 12/21/21 2:00 PM | AZ Alkmaar | FC Groningen | 1-0 | 2 - 4 points |
| 12/22/21 11:45 AM | 12/22/21 11:45 AM | Willem II Tilburg | NEC Nijmwegen | 0-1 | 2 - 4 points |
| 12/22/21 11:45 AM | 12/22/21 11:45 AM | SC Heerenveen | Feyenoord Rotterdam | 0-3 | 2 - 4 points |
| 12/22/21 1:00 PM | 12/22/21 1:00 PM | Heracles Almelo | Cambuur-Leeuwarden | 1-1 | 2 - 4 points |
| 12/22/21 2:00 PM | 12/22/21 2:00 PM | FC Utrecht | FC Twente Enschede | 1-1 | 2 - 4 points |
| 12/22/21 2:00 PM | 12/22/21 2:00 PM | Ajax Amsterdam | Fortuna Sittard | 5-0 | 2 - 4 points |
| 12/23/21 11:45 AM | 12/23/21 11:45 AM | PSV Eindhoven | Go Ahead Eagles Deventer | 2-0 | 2 - 4 points |
| 12/23/21 2:00 PM | 12/23/21 2:00 PM | Sparta Rotterdam | RKC Waalwijk | 1-1 | 2 - 4 points |