Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 1/14/22 1:00 PM | 1/14/22 1:00 PM | PEC Zwolle | Willem II Tilburg | 2-0 | 2 - 4 points |
| 1/15/22 11:45 AM | 1/15/22 11:45 AM | NEC Nijmwegen | Heracles Almelo | 0-0 | 2 - 4 points |
| 1/15/22 1:00 PM | 1/15/22 1:00 PM | Feyenoord Rotterdam | Vitesse Arnheim | 0-1 | 2 - 4 points |
| 1/15/22 1:00 PM | 1/15/22 1:00 PM | FC Twente Enschede | SC Heerenveen | 2-0 | 2 - 4 points |
| 1/15/22 2:00 PM | 1/15/22 2:00 PM | Go Ahead Eagles Deventer | RKC Waalwijk | 0-2 | 2 - 4 points |
| 1/16/22 5:15 AM | 1/16/22 5:15 AM | FC Utrecht | Ajax Amsterdam | 0-3 | 2 - 4 points |
| 1/16/22 7:30 AM | 1/16/22 7:30 AM | Cambuur-Leeuwarden | Sparta Rotterdam | 1-1 | 2 - 4 points |
| 1/16/22 7:30 AM | 1/16/22 7:30 AM | FC Groningen | PSV Eindhoven | 0-1 | 2 - 4 points |
| 1/16/22 9:45 AM | 1/16/22 9:45 AM | Fortuna Sittard | AZ Alkmaar | 1-2 | 2 - 4 points |