Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/20/21 1:00 PM | 8/20/21 1:00 PM | NEC Nijmwegen | PEC Zwolle | 2-0 | 2 - 4 points |
| 8/21/21 11:45 AM | 8/21/21 11:45 AM | SC Heerenveen | RKC Waalwijk | 3-2 | 2 - 4 points |
| 8/21/21 1:00 PM | 8/21/21 1:00 PM | PSV Eindhoven | Cambuur-Leeuwarden | 4-1 | 2 - 4 points |
| 8/21/21 1:00 PM | 8/21/21 1:00 PM | Sparta Rotterdam | Heracles Almelo | 1-1 | 2 - 4 points |
| 8/21/21 2:00 PM | 8/21/21 2:00 PM | FC Groningen | FC Utrecht | 0-0 | 2 - 4 points |
| 8/22/21 5:15 AM | 8/22/21 5:15 AM | FC Twente Enschede | Ajax Amsterdam | 1-1 | 2 - 4 points |
| 8/22/21 7:30 AM | 8/22/21 7:30 AM | Feyenoord Rotterdam | Go Ahead Eagles Deventer | 2-0 | 2 - 4 points |
| 8/22/21 9:45 AM | 8/22/21 9:45 AM | Vitesse Arnheim | Willem II Tilburg | 0-3 | 2 - 4 points |
| 12/2/21 11:45 AM | 12/2/21 11:45 AM | AZ Alkmaar | Fortuna Sittard | 2-1 | 2 - 4 points |