Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 1/22/22 11:45 AM | 1/22/22 11:45 AM | Vitesse Arnheim | FC Groningen | 1-3 | 2 - 4 points |
| 1/22/22 1:00 PM | 1/22/22 1:00 PM | AZ Alkmaar | Cambuur-Leeuwarden | 0-0 | 2 - 4 points |
| 1/22/22 1:00 PM | 1/22/22 1:00 PM | SC Heerenveen | PEC Zwolle | 0-1 | 2 - 4 points |
| 1/22/22 2:00 PM | 1/22/22 2:00 PM | Willem II Tilburg | FC Twente Enschede | 0-1 | 2 - 4 points |
| 1/23/22 5:15 AM | 1/23/22 5:15 AM | NEC Nijmwegen | Feyenoord Rotterdam | 1-4 | 2 - 4 points |
| 1/23/22 7:30 AM | 1/23/22 7:30 AM | PSV Eindhoven | Ajax Amsterdam | 1-2 | 2 - 4 points |
| 1/23/22 7:30 AM | 1/23/22 7:30 AM | Heracles Almelo | Go Ahead Eagles Deventer | 1-1 | 2 - 4 points |
| 1/23/22 9:45 AM | 1/23/22 9:45 AM | Sparta Rotterdam | FC Utrecht | 0-3 | 2 - 4 points |
| 1/23/22 1:00 PM | 1/23/22 1:00 PM | RKC Waalwijk | Fortuna Sittard | 2-1 | 2 - 4 points |