Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/5/22 9:30 AM | 2/5/22 9:30 AM | FC Utrecht | Cambuur-Leeuwarden | 3-2 | 2 - 4 points |
| 2/5/22 11:45 AM | 2/5/22 11:45 AM | Fortuna Sittard | SC Heerenveen | 2-0 | 2 - 4 points |
| 2/5/22 1:00 PM | 2/5/22 1:00 PM | PSV Eindhoven | AZ Alkmaar | 1-2 | 2 - 4 points |
| 2/5/22 1:00 PM | 2/5/22 1:00 PM | PEC Zwolle | NEC Nijmwegen | 1-1 | 2 - 4 points |
| 2/5/22 2:00 PM | 2/5/22 2:00 PM | FC Twente Enschede | Vitesse Arnheim | 3-0 | 2 - 4 points |
| 2/6/22 5:15 AM | 2/6/22 5:15 AM | Feyenoord Rotterdam | Sparta Rotterdam | 4-0 | 2 - 4 points |
| 2/6/22 7:30 AM | 2/6/22 7:30 AM | FC Groningen | Go Ahead Eagles Deventer | 2-1 | 2 - 4 points |
| 2/6/22 7:30 AM | 2/6/22 7:30 AM | Willem II Tilburg | RKC Waalwijk | 3-1 | 2 - 4 points |
| 2/6/22 9:45 AM | 2/6/22 9:45 AM | Ajax Amsterdam | Heracles Almelo | 3-0 | 2 - 4 points |