Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/11/22 1:00 PM | 2/11/22 1:00 PM | Heracles Almelo | FC Utrecht | 1-0 | 2 - 4 points |
| 2/12/22 11:45 AM | 2/12/22 11:45 AM | Cambuur-Leeuwarden | PEC Zwolle | 3-4 | 2 - 4 points |
| 2/12/22 11:45 AM | 2/12/22 11:45 AM | FC Groningen | Fortuna Sittard | 0-1 | 2 - 4 points |
| 2/12/22 1:00 PM | 2/12/22 1:00 PM | Vitesse Arnheim | PSV Eindhoven | 0-5 | 2 - 4 points |
| 2/13/22 5:15 AM | 2/13/22 5:15 AM | Sparta Rotterdam | Willem II Tilburg | 1-0 | 2 - 4 points |
| 2/13/22 5:15 AM | 2/13/22 5:15 AM | Go Ahead Eagles Deventer | AZ Alkmaar | 1-4 | 2 - 4 points |
| 2/13/22 7:30 AM | 2/13/22 7:30 AM | RKC Waalwijk | Feyenoord Rotterdam | 0-2 | 2 - 4 points |
| 2/13/22 7:30 AM | 2/13/22 7:30 AM | SC Heerenveen | NEC Nijmwegen | 0-1 | 2 - 4 points |
| 2/13/22 9:45 AM | 2/13/22 9:45 AM | Ajax Amsterdam | FC Twente Enschede | 5-0 | 2 - 4 points |