Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/19/22 9:30 AM | 2/19/22 9:30 AM | NEC Nijmwegen | RKC Waalwijk | 1-1 | 2 - 4 points |
| 2/19/22 11:45 AM | 2/19/22 11:45 AM | Willem II Tilburg | Ajax Amsterdam | 0-1 | 2 - 4 points |
| 2/19/22 2:00 PM | 2/19/22 2:00 PM | AZ Alkmaar | Heracles Almelo | 2-1 | 2 - 4 points |
| 2/20/22 5:20 AM | 2/20/22 5:20 AM | PEC Zwolle | FC Groningen | 1-1 | 2 - 4 points |
| 2/20/22 7:30 AM | 2/20/22 7:30 AM | FC Twente Enschede | Go Ahead Eagles Deventer | 2-2 | 2 - 4 points |
| 2/20/22 7:30 AM | 2/20/22 7:30 AM | Feyenoord Rotterdam | Cambuur-Leeuwarden | 3-1 | 2 - 4 points |
| 2/20/22 9:45 AM | 2/20/22 9:45 AM | PSV Eindhoven | SC Heerenveen | 3-1 | 2 - 4 points |
| 2/20/22 9:45 AM | 2/20/22 9:45 AM | FC Utrecht | Vitesse Arnheim | 1-1 | 2 - 4 points |
| 4/16/22 11:45 AM | 4/16/22 11:45 AM | Fortuna Sittard | Sparta Rotterdam | 3-0 | 2 - 4 points |