Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/5/22 9:30 AM | 3/5/22 9:30 AM | Willem II Tilburg | SC Heerenveen | 0-0 | 2 - 4 points |
| 3/5/22 11:45 AM | 3/5/22 11:45 AM | Go Ahead Eagles Deventer | FC Utrecht | 1-1 | 2 - 4 points |
| 3/5/22 2:00 PM | 3/5/22 2:00 PM | Feyenoord Rotterdam | FC Groningen | 1-1 | 2 - 4 points |
| 3/6/22 5:15 AM | 3/6/22 5:15 AM | PSV Eindhoven | Heracles Almelo | 3-1 | 2 - 4 points |
| 3/6/22 7:30 AM | 3/6/22 7:30 AM | FC Twente Enschede | Cambuur-Leeuwarden | 1-0 | 2 - 4 points |
| 3/6/22 9:45 AM | 3/6/22 9:45 AM | Ajax Amsterdam | RKC Waalwijk | 3-2 | 2 - 4 points |
| 3/6/22 9:45 AM | 3/6/22 9:45 AM | NEC Nijmwegen | AZ Alkmaar | 1-3 | 2 - 4 points |
| 3/6/22 1:00 PM | 3/6/22 1:00 PM | Fortuna Sittard | PEC Zwolle | 0-1 | 2 - 4 points |
| 4/19/22 11:45 AM | 4/19/22 11:45 AM | Vitesse Arnheim | Sparta Rotterdam | 0-1 | 2 - 4 points |