Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/11/22 1:00 PM | 3/11/22 1:00 PM | Cambuur-Leeuwarden | Ajax Amsterdam | 2-3 | 2 - 4 points |
| 3/12/22 9:30 AM | 3/12/22 9:30 AM | Sparta Rotterdam | Go Ahead Eagles Deventer | 1-0 | 2 - 4 points |
| 3/12/22 11:45 AM | 3/12/22 11:45 AM | FC Groningen | NEC Nijmwegen | 4-3 | 2 - 4 points |
| 3/12/22 2:00 PM | 3/12/22 2:00 PM | RKC Waalwijk | SC Heerenveen | 0-0 | 2 - 4 points |
| 3/13/22 6:15 AM | 3/13/22 6:15 AM | Fortuna Sittard | Willem II Tilburg | 1-0 | 2 - 4 points |
| 3/13/22 8:30 AM | 3/13/22 8:30 AM | FC Utrecht | PSV Eindhoven | 0-1 | 2 - 4 points |
| 3/13/22 8:30 AM | 3/13/22 8:30 AM | Heracles Almelo | Vitesse Arnheim | 0-0 | 2 - 4 points |
| 3/13/22 10:45 AM | 3/13/22 10:45 AM | PEC Zwolle | Feyenoord Rotterdam | 1-2 | 2 - 4 points |
| 3/13/22 2:00 PM | 3/13/22 2:00 PM | AZ Alkmaar | FC Twente Enschede | 0-1 | 2 - 4 points |