Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/18/22 2:00 PM | 3/18/22 2:00 PM | SC Heerenveen | Heracles Almelo | 2-0 | 2 - 4 points |
| 3/19/22 12:45 PM | 3/19/22 12:45 PM | Go Ahead Eagles Deventer | Cambuur-Leeuwarden | 3-0 | 2 - 4 points |
| 3/19/22 2:00 PM | 3/19/22 2:00 PM | FC Twente Enschede | PEC Zwolle | 1-0 | 2 - 4 points |
| 3/19/22 3:00 PM | 3/19/22 3:00 PM | NEC Nijmwegen | Sparta Rotterdam | 0-0 | 2 - 4 points |
| 3/20/22 6:15 AM | 3/20/22 6:15 AM | FC Utrecht | FC Groningen | 1-3 | 2 - 4 points |
| 3/20/22 8:35 AM | 3/20/22 8:35 AM | Ajax Amsterdam | Feyenoord Rotterdam | 3-2 | 2 - 4 points |
| 3/20/22 10:45 AM | 3/20/22 10:45 AM | PSV Eindhoven | Fortuna Sittard | 5-0 | 2 - 4 points |
| 3/20/22 10:45 AM | 3/20/22 10:45 AM | Vitesse Arnheim | RKC Waalwijk | 1-2 | 2 - 4 points |
| 3/20/22 2:00 PM | 3/20/22 2:00 PM | Willem II Tilburg | AZ Alkmaar | 2-2 | 2 - 4 points |