Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/2/22 9:30 AM | 4/2/22 9:30 AM | FC Groningen | Ajax Amsterdam | 1-3 | 2 - 4 points |
| 4/2/22 11:45 AM | 4/2/22 11:45 AM | FC Twente Enschede | PSV Eindhoven | 3-3 | 2 - 4 points |
| 4/2/22 1:00 PM | 4/2/22 1:00 PM | AZ Alkmaar | Vitesse Arnheim | 3-1 | 2 - 4 points |
| 4/2/22 1:00 PM | 4/2/22 1:00 PM | RKC Waalwijk | FC Utrecht | 1-1 | 2 - 4 points |
| 4/2/22 2:00 PM | 4/2/22 2:00 PM | Feyenoord Rotterdam | Willem II Tilburg | 2-0 | 2 - 4 points |
| 4/3/22 5:15 AM | 4/3/22 5:15 AM | PEC Zwolle | Go Ahead Eagles Deventer | 0-1 | 2 - 4 points |
| 4/3/22 7:30 AM | 4/3/22 7:30 AM | Fortuna Sittard | Heracles Almelo | 0-2 | 2 - 4 points |
| 4/3/22 7:30 AM | 4/3/22 7:30 AM | Sparta Rotterdam | SC Heerenveen | 1-1 | 2 - 4 points |
| 4/3/22 9:45 AM | 4/3/22 9:45 AM | Cambuur-Leeuwarden | NEC Nijmwegen | 1-2 | 2 - 4 points |