Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/8/22 1:00 PM | 4/8/22 1:00 PM | Go Ahead Eagles Deventer | Willem II Tilburg | 4-0 | 2 - 4 points |
| 4/9/22 11:45 AM | 4/9/22 11:45 AM | FC Utrecht | Fortuna Sittard | 1-1 | 2 - 4 points |
| 4/9/22 1:00 PM | 4/9/22 1:00 PM | Ajax Amsterdam | Sparta Rotterdam | 2-1 | 2 - 4 points |
| 4/9/22 2:00 PM | 4/9/22 2:00 PM | NEC Nijmwegen | FC Twente Enschede | 0-2 | 2 - 4 points |
| 4/10/22 5:15 AM | 4/10/22 5:15 AM | SC Heerenveen | FC Groningen | 3-1 | 2 - 4 points |
| 4/10/22 7:30 AM | 4/10/22 7:30 AM | Vitesse Arnheim | Cambuur-Leeuwarden | 1-0 | 2 - 4 points |
| 4/10/22 7:30 AM | 4/10/22 7:30 AM | PSV Eindhoven | RKC Waalwijk | 2-0 | 2 - 4 points |
| 4/10/22 9:45 AM | 4/10/22 9:45 AM | Heracles Almelo | Feyenoord Rotterdam | 1-4 | 2 - 4 points |
| 4/10/22 1:00 PM | 4/10/22 1:00 PM | PEC Zwolle | AZ Alkmaar | 2-1 | 2 - 4 points |