Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/27/21 1:00 PM | 8/27/21 1:00 PM | Fortuna Sittard | RKC Waalwijk | 2-2 | 2 - 4 points |
| 8/28/21 11:45 AM | 8/28/21 11:45 AM | Cambuur-Leeuwarden | FC Twente Enschede | 2-0 | 2 - 4 points |
| 8/28/21 1:00 PM | 8/28/21 1:00 PM | Go Ahead Eagles Deventer | Sparta Rotterdam | 2-0 | 2 - 4 points |
| 8/28/21 1:00 PM | 8/28/21 1:00 PM | PSV Eindhoven | FC Groningen | 5-2 | 2 - 4 points |
| 8/28/21 2:00 PM | 8/28/21 2:00 PM | Willem II Tilburg | PEC Zwolle | 1-0 | 2 - 4 points |
| 8/29/21 5:15 AM | 8/29/21 5:15 AM | FC Utrecht | Feyenoord Rotterdam | 3-1 | 2 - 4 points |
| 8/29/21 7:30 AM | 8/29/21 7:30 AM | Heracles Almelo | NEC Nijmwegen | 0-1 | 2 - 4 points |
| 8/29/21 7:30 AM | 8/29/21 7:30 AM | Ajax Amsterdam | Vitesse Arnheim | 5-0 | 2 - 4 points |
| 8/29/21 9:45 AM | 8/29/21 9:45 AM | SC Heerenveen | AZ Alkmaar | 1-3 | 2 - 4 points |