Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/22/22 1:00 PM | 4/22/22 1:00 PM | FC Twente Enschede | Sparta Rotterdam | 2-0 | 2 - 4 points |
| 4/23/22 9:30 AM | 4/23/22 9:30 AM | NEC Nijmwegen | Ajax Amsterdam | 0-1 | 2 - 4 points |
| 4/23/22 11:45 AM | 4/23/22 11:45 AM | AZ Alkmaar | SC Heerenveen | 2-1 | 2 - 4 points |
| 4/23/22 1:00 PM | 4/23/22 1:00 PM | RKC Waalwijk | PEC Zwolle | 0-2 | 2 - 4 points |
| 4/23/22 2:00 PM | 4/23/22 2:00 PM | Cambuur-Leeuwarden | PSV Eindhoven | 1-2 | 2 - 4 points |
| 4/24/22 5:15 AM | 4/24/22 5:15 AM | Willem II Tilburg | Vitesse Arnheim | 1-0 | 2 - 4 points |
| 4/24/22 7:30 AM | 4/24/22 7:30 AM | FC Groningen | Heracles Almelo | 0-1 | 2 - 4 points |
| 4/24/22 7:30 AM | 4/24/22 7:30 AM | Feyenoord Rotterdam | FC Utrecht | 2-1 | 2 - 4 points |
| 4/24/22 9:45 AM | 4/24/22 9:45 AM | Fortuna Sittard | Go Ahead Eagles Deventer | 1-0 | 2 - 4 points |