Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/29/22 1:00 PM | 4/29/22 1:00 PM | FC Utrecht | NEC Nijmwegen | 1-0 | 2 - 4 points |
| 4/30/22 11:45 AM | 4/30/22 11:45 AM | Ajax Amsterdam | PEC Zwolle | 3-0 | 2 - 4 points |
| 4/30/22 1:00 PM | 4/30/22 1:00 PM | Heracles Almelo | FC Twente Enschede | 1-1 | 2 - 4 points |
| 4/30/22 2:00 PM | 4/30/22 2:00 PM | Sparta Rotterdam | AZ Alkmaar | 1-1 | 2 - 4 points |
| 5/1/22 5:15 AM | 5/1/22 5:15 AM | SC Heerenveen | Cambuur-Leeuwarden | 3-3 | 2 - 4 points |
| 5/1/22 7:30 AM | 5/1/22 7:30 AM | Go Ahead Eagles Deventer | Vitesse Arnheim | 1-2 | 2 - 4 points |
| 5/1/22 7:30 AM | 5/1/22 7:30 AM | PSV Eindhoven | Willem II Tilburg | 4-2 | 2 - 4 points |
| 5/1/22 9:45 AM | 5/1/22 9:45 AM | Fortuna Sittard | Feyenoord Rotterdam | 1-3 | 2 - 4 points |
| 5/1/22 1:00 PM | 5/1/22 1:00 PM | RKC Waalwijk | FC Groningen | 3-1 | 2 - 4 points |