Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | Cambuur-Leeuwarden | Willem II Tilburg | 1-1 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | Go Ahead Eagles Deventer | Feyenoord Rotterdam | 0-1 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | PSV Eindhoven | NEC Nijmwegen | 3-2 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | FC Twente Enschede | FC Groningen | 3-0 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | Sparta Rotterdam | PEC Zwolle | 2-0 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | FC Utrecht | AZ Alkmaar | 2-2 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | Ajax Amsterdam | SC Heerenveen | 5-0 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | Fortuna Sittard | Vitesse Arnheim | 1-2 | 2 - 4 points |
| 5/11/22 1:00 PM | 5/11/22 1:00 PM | RKC Waalwijk | Heracles Almelo | 2-0 | 2 - 4 points |