Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/11/21 9:30 AM | 9/11/21 9:30 AM | FC Twente Enschede | FC Utrecht | 1-0 | 2 - 4 points |
| 9/11/21 11:45 AM | 9/11/21 11:45 AM | Cambuur-Leeuwarden | Go Ahead Eagles Deventer | 5-2 | 2 - 4 points |
| 9/11/21 11:45 AM | 9/11/21 11:45 AM | PEC Zwolle | Ajax Amsterdam | 0-2 | 2 - 4 points |
| 9/11/21 2:00 PM | 9/11/21 2:00 PM | AZ Alkmaar | PSV Eindhoven | 0-3 | 2 - 4 points |
| 9/12/21 5:15 AM | 9/12/21 5:15 AM | NEC Nijmwegen | Willem II Tilburg | 0-0 | 2 - 4 points |
| 9/12/21 7:30 AM | 9/12/21 7:30 AM | Sparta Rotterdam | Fortuna Sittard | 3-1 | 2 - 4 points |
| 9/12/21 7:30 AM | 9/12/21 7:30 AM | FC Groningen | SC Heerenveen | 1-1 | 2 - 4 points |
| 9/12/21 9:45 AM | 9/12/21 9:45 AM | RKC Waalwijk | Vitesse Arnheim | 1-2 | 2 - 4 points |
| 12/1/21 1:00 PM | 12/1/21 1:00 PM | Feyenoord Rotterdam | Heracles Almelo | 2-1 | 2 - 4 points |