Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/25/21 9:30 AM | 9/25/21 9:30 AM | Willem II Tilburg | PSV Eindhoven | 2-1 | 2 - 4 points |
| 9/25/21 11:45 AM | 9/25/21 11:45 AM | Vitesse Arnheim | Fortuna Sittard | 1-1 | 2 - 4 points |
| 9/25/21 11:45 AM | 9/25/21 11:45 AM | Ajax Amsterdam | FC Groningen | 3-0 | 2 - 4 points |
| 9/25/21 2:00 PM | 9/25/21 2:00 PM | FC Utrecht | PEC Zwolle | 5-1 | 2 - 4 points |
| 9/25/21 2:00 PM | 9/25/21 2:00 PM | Feyenoord Rotterdam | NEC Nijmwegen | 5-3 | 2 - 4 points |
| 9/26/21 5:15 AM | 9/26/21 5:15 AM | Sparta Rotterdam | Cambuur-Leeuwarden | 0-4 | 2 - 4 points |
| 9/26/21 7:30 AM | 9/26/21 7:30 AM | SC Heerenveen | FC Twente Enschede | 2-3 | 2 - 4 points |
| 9/26/21 7:30 AM | 9/26/21 7:30 AM | AZ Alkmaar | Go Ahead Eagles Deventer | 5-0 | 2 - 4 points |
| 9/26/21 9:45 AM | 9/26/21 9:45 AM | Heracles Almelo | RKC Waalwijk | 1-0 | 2 - 4 points |