Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/1/21 1:00 PM | 10/1/21 1:00 PM | FC Groningen | FC Twente Enschede | 1-1 | 2 - 4 points |
| 10/2/21 11:45 AM | 10/2/21 11:45 AM | RKC Waalwijk | Go Ahead Eagles Deventer | 1-1 | 2 - 4 points |
| 10/2/21 1:00 PM | 10/2/21 1:00 PM | Heracles Almelo | Willem II Tilburg | 3-2 | 2 - 4 points |
| 10/2/21 1:00 PM | 10/2/21 1:00 PM | PEC Zwolle | SC Heerenveen | 0-1 | 2 - 4 points |
| 10/2/21 2:00 PM | 10/2/21 2:00 PM | Fortuna Sittard | NEC Nijmwegen | 1-3 | 2 - 4 points |
| 10/3/21 7:30 AM | 10/3/21 7:30 AM | Ajax Amsterdam | FC Utrecht | 0-1 | 2 - 4 points |
| 10/3/21 7:30 AM | 10/3/21 7:30 AM | Cambuur-Leeuwarden | AZ Alkmaar | 1-3 | 2 - 4 points |
| 10/3/21 9:45 AM | 10/3/21 9:45 AM | Vitesse Arnheim | Feyenoord Rotterdam | 2-1 | 2 - 4 points |
| 10/3/21 1:00 PM | 10/3/21 1:00 PM | PSV Eindhoven | Sparta Rotterdam | 2-1 | 2 - 4 points |