Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/16/21 9:30 AM | 10/16/21 9:30 AM | Feyenoord Rotterdam | RKC Waalwijk | 2-2 | 2 - 4 points |
| 10/16/21 11:45 AM | 10/16/21 11:45 AM | SC Heerenveen | Ajax Amsterdam | 0-2 | 2 - 4 points |
| 10/16/21 11:45 AM | 10/16/21 11:45 AM | Go Ahead Eagles Deventer | Heracles Almelo | 4-2 | 2 - 4 points |
| 10/16/21 2:00 PM | 10/16/21 2:00 PM | Fortuna Sittard | Cambuur-Leeuwarden | 1-0 | 2 - 4 points |
| 10/16/21 2:00 PM | 10/16/21 2:00 PM | PSV Eindhoven | PEC Zwolle | 3-1 | 2 - 4 points |
| 10/17/21 5:15 AM | 10/17/21 5:15 AM | AZ Alkmaar | FC Utrecht | 5-1 | 2 - 4 points |
| 10/17/21 7:30 AM | 10/17/21 7:30 AM | Sparta Rotterdam | FC Groningen | 1-1 | 2 - 4 points |
| 10/17/21 7:30 AM | 10/17/21 7:30 AM | NEC Nijmwegen | Vitesse Arnheim | 0-1 | 2 - 4 points |
| 10/17/21 9:45 AM | 10/17/21 9:45 AM | FC Twente Enschede | Willem II Tilburg | 1-1 | 2 - 4 points |