Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/13/21 2:00 PM | 8/13/21 2:00 PM | Brentford FC | Arsenal FC | 2-0 | 1 - 4 points |
| 8/14/21 6:30 AM | 8/14/21 6:30 AM | Manchester United | Leeds United | 5-1 | 1 - 4 points |
| 8/14/21 9:00 AM | 8/14/21 9:00 AM | Leicester City | Wolverhampton Wanderers | 1-0 | 1 - 4 points |
| 8/14/21 9:00 AM | 8/14/21 9:00 AM | Burnley FC | Brighton and Hove Albion | 1-2 | 1 - 4 points |
| 8/14/21 9:00 AM | 8/14/21 9:00 AM | Chelsea FC | Crystal Palace | 3-0 | 1 - 4 points |
| 8/14/21 9:00 AM | 8/14/21 9:00 AM | Everton FC | Southampton FC | 3-1 | 1 - 4 points |
| 8/14/21 9:00 AM | 8/14/21 9:00 AM | Watford FC | Aston Villa | 3-2 | 1 - 4 points |
| 8/14/21 11:30 AM | 8/14/21 11:30 AM | Norwich City | Liverpool FC | 0-3 | 1 - 4 points |
| 8/15/21 8:00 AM | 8/15/21 8:00 AM | Newcastle United | West Ham United | 2-4 | 1 - 4 points |
| 8/15/21 10:30 AM | 8/15/21 10:30 AM | Tottenham Hotspur | Manchester City | 1-0 | 1 - 4 points |