Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/21/21 6:30 AM | 8/21/21 6:30 AM | Liverpool FC | Burnley FC | 2-0 | 1 - 4 points |
| 8/21/21 9:00 AM | 8/21/21 9:00 AM | Aston Villa | Newcastle United | 2-0 | 1 - 4 points |
| 8/21/21 9:00 AM | 8/21/21 9:00 AM | Crystal Palace | Brentford FC | 0-0 | 1 - 4 points |
| 8/21/21 9:00 AM | 8/21/21 9:00 AM | Manchester City | Norwich City | 5-0 | 1 - 4 points |
| 8/21/21 9:00 AM | 8/21/21 9:00 AM | Leeds United | Everton FC | 2-2 | 1 - 4 points |
| 8/21/21 11:30 AM | 8/21/21 11:30 AM | Brighton and Hove Albion | Watford FC | 2-0 | 1 - 4 points |
| 8/22/21 8:00 AM | 8/22/21 8:00 AM | Southampton FC | Manchester United | 1-1 | 1 - 4 points |
| 8/22/21 8:00 AM | 8/22/21 8:00 AM | Wolverhampton Wanderers | Tottenham Hotspur | 0-1 | 1 - 4 points |
| 8/22/21 10:30 AM | 8/22/21 10:30 AM | Arsenal FC | Chelsea FC | 0-2 | 1 - 4 points |
| 8/23/21 2:00 PM | 8/23/21 2:00 PM | West Ham United | Leicester City | 4-1 | 1 - 4 points |