Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/11/21 6:30 AM | 9/11/21 6:30 AM | Crystal Palace | Tottenham Hotspur | 3-0 | 1 - 4 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Brentford FC | Brighton and Hove Albion | 0-1 | 1 - 4 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Leicester City | Manchester City | 0-1 | 1 - 4 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Manchester United | Newcastle United | 4-1 | 1 - 4 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Southampton FC | West Ham United | 0-0 | 1 - 4 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Arsenal FC | Norwich City | 1-0 | 1 - 4 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Watford FC | Wolverhampton Wanderers | 0-2 | 1 - 4 points |
| 9/11/21 11:30 AM | 9/11/21 11:30 AM | Chelsea FC | Aston Villa | 3-0 | 1 - 4 points |
| 9/12/21 10:30 AM | 9/12/21 10:30 AM | Leeds United | Liverpool FC | 0-3 | 1 - 4 points |
| 9/13/21 2:00 PM | 9/13/21 2:00 PM | Everton FC | Burnley FC | 3-1 | 1 - 4 points |