Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 2:00 PM | 9/17/21 2:00 PM | Newcastle United | Leeds United | 1-1 | 1 - 4 points |
| 9/18/21 6:30 AM | 9/18/21 6:30 AM | Wolverhampton Wanderers | Brentford FC | 0-2 | 1 - 4 points |
| 9/18/21 9:00 AM | 9/18/21 9:00 AM | Burnley FC | Arsenal FC | 0-1 | 1 - 4 points |
| 9/18/21 9:00 AM | 9/18/21 9:00 AM | Liverpool FC | Crystal Palace | 3-0 | 1 - 4 points |
| 9/18/21 9:00 AM | 9/18/21 9:00 AM | Manchester City | Southampton FC | 0-0 | 1 - 4 points |
| 9/18/21 9:00 AM | 9/18/21 9:00 AM | Norwich City | Watford FC | 1-3 | 1 - 4 points |
| 9/18/21 11:30 AM | 9/18/21 11:30 AM | Aston Villa | Everton FC | 3-0 | 1 - 4 points |
| 9/19/21 8:00 AM | 9/19/21 8:00 AM | West Ham United | Manchester United | 1-2 | 1 - 4 points |
| 9/19/21 8:00 AM | 9/19/21 8:00 AM | Brighton and Hove Albion | Leicester City | 2-1 | 1 - 4 points |
| 9/19/21 10:30 AM | 9/19/21 10:30 AM | Tottenham Hotspur | Chelsea FC | 0-3 | 1 - 4 points |