Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/25/21 6:30 AM | 9/25/21 6:30 AM | Manchester United | Aston Villa | 0-1 | 1 - 4 points |
| 9/25/21 6:30 AM | 9/25/21 6:30 AM | Chelsea FC | Manchester City | 0-1 | 1 - 4 points |
| 9/25/21 9:00 AM | 9/25/21 9:00 AM | Leeds United | West Ham United | 1-2 | 1 - 4 points |
| 9/25/21 9:00 AM | 9/25/21 9:00 AM | Leicester City | Burnley FC | 2-2 | 1 - 4 points |
| 9/25/21 9:00 AM | 9/25/21 9:00 AM | Watford FC | Newcastle United | 1-1 | 1 - 4 points |
| 9/25/21 9:00 AM | 9/25/21 9:00 AM | Everton FC | Norwich City | 2-0 | 1 - 4 points |
| 9/25/21 11:30 AM | 9/25/21 11:30 AM | Brentford FC | Liverpool FC | 3-3 | 1 - 4 points |
| 9/26/21 8:00 AM | 9/26/21 8:00 AM | Southampton FC | Wolverhampton Wanderers | 0-1 | 1 - 4 points |
| 9/26/21 10:30 AM | 9/26/21 10:30 AM | Arsenal FC | Tottenham Hotspur | 3-1 | 1 - 4 points |
| 9/27/21 2:00 PM | 9/27/21 2:00 PM | Crystal Palace | Brighton and Hove Albion | 1-1 | 1 - 4 points |