Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/16/21 6:30 AM | 10/16/21 6:30 AM | Watford FC | Liverpool FC | 0-5 | 1 - 4 points |
| 10/16/21 9:00 AM | 10/16/21 9:00 AM | Aston Villa | Wolverhampton Wanderers | 2-3 | 1 - 4 points |
| 10/16/21 9:00 AM | 10/16/21 9:00 AM | Leicester City | Manchester United | 4-2 | 1 - 4 points |
| 10/16/21 9:00 AM | 10/16/21 9:00 AM | Manchester City | Burnley FC | 2-0 | 1 - 4 points |
| 10/16/21 9:00 AM | 10/16/21 9:00 AM | Norwich City | Brighton and Hove Albion | 0-0 | 1 - 4 points |
| 10/16/21 9:00 AM | 10/16/21 9:00 AM | Southampton FC | Leeds United | 1-0 | 1 - 4 points |
| 10/16/21 11:30 AM | 10/16/21 11:30 AM | Brentford FC | Chelsea FC | 0-1 | 1 - 4 points |
| 10/17/21 8:00 AM | 10/17/21 8:00 AM | Everton FC | West Ham United | 0-1 | 1 - 4 points |
| 10/17/21 10:30 AM | 10/17/21 10:30 AM | Newcastle United | Tottenham Hotspur | 2-3 | 1 - 4 points |
| 10/18/21 2:00 PM | 10/18/21 2:00 PM | Arsenal FC | Crystal Palace | 2-2 | 1 - 4 points |