Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/22/21 2:00 PM | 10/22/21 2:00 PM | Arsenal FC | Aston Villa | 3-1 | 1 - 4 points |
| 10/23/21 6:30 AM | 10/23/21 6:30 AM | Chelsea FC | Norwich City | 7-0 | 1 - 4 points |
| 10/23/21 9:00 AM | 10/23/21 9:00 AM | Crystal Palace | Newcastle United | 1-1 | 1 - 4 points |
| 10/23/21 9:00 AM | 10/23/21 9:00 AM | Everton FC | Watford FC | 2-5 | 1 - 4 points |
| 10/23/21 9:00 AM | 10/23/21 9:00 AM | Leeds United | Wolverhampton Wanderers | 1-1 | 1 - 4 points |
| 10/23/21 9:00 AM | 10/23/21 9:00 AM | Southampton FC | Burnley FC | 2-2 | 1 - 4 points |
| 10/23/21 11:30 AM | 10/23/21 11:30 AM | Brighton and Hove Albion | Manchester City | 1-4 | 1 - 4 points |
| 10/24/21 8:00 AM | 10/24/21 8:00 AM | Brentford FC | Leicester City | 1-2 | 1 - 4 points |
| 10/24/21 8:00 AM | 10/24/21 8:00 AM | West Ham United | Tottenham Hotspur | 1-0 | 1 - 4 points |
| 10/24/21 10:30 AM | 10/24/21 10:30 AM | Manchester United | Liverpool FC | 0-5 | 1 - 4 points |