| Date | Home | Away | Result |
|---|---|---|---|
| 5/22/21 8:30 AM | VfB Stuttgart | Arminia Bielefeld | 0-2 |
| 5/22/21 8:30 AM | VfL Wolfsburg | FSV Mainz 05 | 2-3 |
| 5/22/21 8:30 AM | Eintracht Frankfurt | SC Freiburg | 3-1 |
| 5/22/21 8:30 AM | 1. FC Köln | FC Schalke 04 | 1-0 |
| 5/22/21 8:30 AM | 1899 Hoffenheim | Hertha BSC | 2-1 |
| 5/22/21 8:30 AM | Borussia Dortmund | Bayer 04 Leverkusen | 3-1 |
| 5/22/21 8:30 AM | 1. FC Union Berlin | RB Leipzig | 2-1 |
| 5/22/21 8:30 AM | Werder Bremen | Bor. Mönchengladbach | 2-4 |
| 5/22/21 8:35 AM | FC Bayern Munich | FC Augsburg | 5-2 |