| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 4/1/25 5:00 PM | Club Cerro Porteno | Club Bolívar | Group G | 4-2 |
| 4/1/25 5:00 PM | Carabobo FC | Estudiantes de La Plata | Group A | 0-2 |
| 4/1/25 7:30 PM | Fortaleza | Racing Club | Group E | 0-3 |
| 4/1/25 7:30 PM | Atlético Bucaramanga | Colo-Colo | Group E | 3-3 |
| 4/1/25 9:00 PM | Alianza Lima | Club Libertad | Group D | 0-1 |
| 4/1/25 9:00 PM | Barcelona SC | Independiente del Valle | Group B | 1-0 |
| 4/2/25 5:00 PM | CA Velez Sarsfield | Club Atlético Peñarol | Group H | 2-1 |
| 4/2/25 5:00 PM | San Antonio Bulo Bulo | Club Olimpia | Group H | 3-2 |
| 4/2/25 7:30 PM | CA Talleres | FC Sao Paulo | Group D | 0-0 |
| 4/2/25 7:30 PM | Universitario | River Plate | Group B | 0-1 |
| 4/2/25 7:30 PM | Universidad de Chile | Botafogo | Group A | 0-0 |
| 4/2/25 9:00 PM | Atlético Nacional | Club Nacional de Football | Group F | --- |
| 4/3/25 5:00 PM | Sporting Cristal | Palmeiras | Group G | --- |
| 4/3/25 5:00 PM | Bahia BA | Internacional | Group F | --- |
| 4/3/25 5:00 PM | Central Cordoba | LDU Quito | Group C | --- |
| 4/3/25 7:30 PM | Deportivo Tachira | Flamengo | Group C | --- |