| Date | Home | Away | Result |
|---|---|---|---|
| 5/21/22 2:00 PM | OSC Lille | Stade Rennes | 2-2 |
| 5/21/22 2:00 PM | FC Lorient | ES Troyes AC | 1-1 |
| 5/21/22 2:00 PM | Olympique Marseille | Racing Club Strasbourg | 4-0 |
| 5/21/22 2:00 PM | FC Nantes | AS St. Etienne | 1-1 |
| 5/21/22 2:00 PM | Paris St. Germain | FC Metz | 5-0 |
| 5/21/22 2:00 PM | Stade Reims | OGC Nice | 2-3 |
| 5/21/22 2:00 PM | SCO Angers | HSC Montpellier | 2-0 |
| 5/21/22 2:00 PM | Stade Brest 29 | Girondins Bordeaux | 2-4 |
| 5/21/22 2:00 PM | Clermont Foot | Olympique Lyon | 1-2 |
| 5/21/22 2:00 PM | RC Lens | AS Monaco | 2-2 |