| Date | Home | Away | Result |
|---|---|---|---|
| 5/22/22 10:00 AM | Chelsea FC | Watford FC | 2-1 |
| 5/22/22 10:00 AM | Crystal Palace | Manchester United | 1-0 |
| 5/22/22 10:00 AM | Leicester City | Southampton FC | 4-1 |
| 5/22/22 10:00 AM | Liverpool FC | Wolverhampton Wanderers | 3-1 |
| 5/22/22 10:00 AM | Manchester City | Aston Villa | 3-2 |
| 5/22/22 10:00 AM | Norwich City | Tottenham Hotspur | 0-5 |
| 5/22/22 10:00 AM | Arsenal FC | Everton FC | 5-1 |
| 5/22/22 10:00 AM | Brentford FC | Leeds United | 1-2 |
| 5/22/22 10:00 AM | Brighton and Hove Albion | West Ham United | 3-1 |
| 5/22/22 10:00 AM | Burnley FC | Newcastle United | 1-2 |