Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/1/21 12:00 PM | 10/1/21 12:00 PM | FC Wegberg-Beeck | 1. FC Köln II | 0-1 | 5 - 7 points |
| 10/1/21 12:30 PM | 10/1/21 12:30 PM | Sportfreunde Lotte | Alemannia Aachen | 1-0 | 5 - 7 points |
| 10/1/21 12:30 PM | 10/1/21 12:30 PM | SC Fortuna Köln | Preußen Münster | 3-2 | 5 - 7 points |
| 10/1/21 12:30 PM | 10/1/21 12:30 PM | SV Rödinghausen | SC Wiedenbrück | 1-0 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Bor. Mönchengladbach II | Bonner SC | 2-1 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Rot-Weiss Essen | Rot-Weiss Oberhausen | 1-1 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Fortuna Düsseldorf II | VfB Homberg | 4-0 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | SV Straelen | SV Lippstadt 08 | 0-2 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Wuppertaler SV | FC Schalke 04 II | 3-0 | 5 - 7 points |
| 10/2/21 7:00 AM | 10/2/21 7:00 AM | Rot-Weiss Ahlen | KFC Uerdingen | 1-0 | 5 - 7 points |