Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/13/22 12:00 PM | 5/13/22 12:00 PM | FC Schalke 04 II | SC Wiedenbrück | 5-1 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | Bonner SC | Rot-Weiss Oberhausen | 1-5 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | VfB Homberg | Alemannia Aachen | 0-0 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | SV Lippstadt 08 | KFC Uerdingen | 3-4 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | Preußen Münster | 1. FC Köln II | 2-1 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | Fortuna Düsseldorf II | Bor. Mönchengladbach II | 0-0 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | SC Fortuna Köln | Sportfreunde Lotte | 2-1 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | Rot-Weiss Essen | Rot-Weiss Ahlen | 2-0 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | Wuppertaler SV | FC Wegberg-Beeck | 4-1 | 5 - 7 points |
| 5/14/22 7:00 AM | 5/14/22 7:00 AM | SV Straelen | SV Rödinghausen | 1-4 | 5 - 7 points |