Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/8/21 11:00 AM | 10/8/21 11:00 AM | SV Lippstadt 08 | Wuppertaler SV | 2-2 | 5 - 7 points |
| 10/8/21 12:30 PM | 10/8/21 12:30 PM | Alemannia Aachen | FC Wegberg-Beeck | 3-2 | 5 - 7 points |
| 10/8/21 12:30 PM | 10/8/21 12:30 PM | SC Wiedenbrück | Rot-Weiss Ahlen | 2-2 | 5 - 7 points |
| 10/9/21 7:00 AM | 10/9/21 7:00 AM | Bonner SC | VfB Homberg | 2-0 | 5 - 7 points |
| 10/9/21 7:00 AM | 10/9/21 7:00 AM | Preußen Münster | Fortuna Düsseldorf II | 2-0 | 5 - 7 points |
| 10/9/21 7:00 AM | 10/9/21 7:00 AM | Bor. Mönchengladbach II | Sportfreunde Lotte | 3-0 | 5 - 7 points |
| 10/9/21 7:00 AM | 10/9/21 7:00 AM | KFC Uerdingen | Rot-Weiss Essen | 0-11 | 5 - 7 points |
| 10/9/21 7:00 AM | 10/9/21 7:00 AM | Rot-Weiss Oberhausen | SV Straelen | 0-0 | 5 - 7 points |
| 10/12/21 7:00 AM | 10/12/21 7:00 AM | FC Schalke 04 II | SC Fortuna Köln | 1-1 | 5 - 7 points |
| 10/27/21 7:00 AM | 10/27/21 7:00 AM | 1. FC Köln II | SV Rödinghausen | 2-3 | 5 - 7 points |