Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/15/21 11:30 AM | 10/15/21 11:30 AM | Fortuna Düsseldorf II | FC Schalke 04 II | 5-1 | 5 - 7 points |
| 10/15/21 12:00 PM | 10/15/21 12:00 PM | Rot-Weiss Ahlen | 1. FC Köln II | 2-6 | 5 - 7 points |
| 10/15/21 12:30 PM | 10/15/21 12:30 PM | FC Wegberg-Beeck | Bor. Mönchengladbach II | 1-0 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | SV Straelen | KFC Uerdingen | 2-0 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | Wuppertaler SV | Rot-Weiss Oberhausen | 1-1 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | SV Rödinghausen | Alemannia Aachen | 1-1 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | Sportfreunde Lotte | Bonner SC | 0-2 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | SC Fortuna Köln | SV Lippstadt 08 | 4-2 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | VfB Homberg | Preußen Münster | 2-2 | 5 - 7 points |
| 10/16/21 7:00 AM | 10/16/21 7:00 AM | Rot-Weiss Essen | SC Wiedenbrück | 0-0 | 5 - 7 points |