Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/22/21 12:30 PM | 10/22/21 12:30 PM | Bonner SC | Preußen Münster | 1-2 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | Alemannia Aachen | Rot-Weiss Ahlen | 1-4 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | FC Schalke 04 II | VfB Homberg | 0-0 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | 1. FC Köln II | Rot-Weiss Essen | 1-1 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | KFC Uerdingen | Wuppertaler SV | 0-2 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | SV Lippstadt 08 | Fortuna Düsseldorf II | 5-2 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | SC Wiedenbrück | SV Straelen | 2-0 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | Sportfreunde Lotte | FC Wegberg-Beeck | 1-2 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | Bor. Mönchengladbach II | SV Rödinghausen | 1-2 | 5 - 7 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | Rot-Weiss Oberhausen | SC Fortuna Köln | 0-2 | 5 - 7 points |