Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/29/21 12:00 PM | 10/29/21 12:00 PM | Preußen Münster | FC Schalke 04 II | 3-0 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | Wuppertaler SV | SC Wiedenbrück | 0-0 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | SC Fortuna Köln | KFC Uerdingen | 4-0 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | SV Straelen | 1. FC Köln II | 1-2 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | FC Wegberg-Beeck | Bonner SC | 1-3 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | VfB Homberg | SV Lippstadt 08 | 3-2 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | SV Rödinghausen | Sportfreunde Lotte | 3-0 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | Rot-Weiss Essen | Alemannia Aachen | 2-1 | 5 - 7 points |
| 10/30/21 7:00 AM | 10/30/21 7:00 AM | Rot-Weiss Ahlen | Bor. Mönchengladbach II | 3-1 | 5 - 7 points |
| 10/31/21 8:00 AM | 10/31/21 8:00 AM | Fortuna Düsseldorf II | Rot-Weiss Oberhausen | 2-2 | 5 - 7 points |