Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/5/21 1:00 PM | 11/5/21 1:00 PM | Bor. Mönchengladbach II | Rot-Weiss Essen | 1-2 | 5 - 7 points |
| 11/5/21 1:00 PM | 11/5/21 1:00 PM | 1. FC Köln II | Wuppertaler SV | 0-3 | 5 - 7 points |
| 11/5/21 1:30 PM | 11/5/21 1:30 PM | Alemannia Aachen | SV Straelen | 5-3 | 5 - 7 points |
| 11/5/21 1:30 PM | 11/5/21 1:30 PM | Preußen Münster | SV Lippstadt 08 | 3-1 | 5 - 7 points |
| 11/6/21 8:00 AM | 11/6/21 8:00 AM | SC Wiedenbrück | SC Fortuna Köln | 0-1 | 5 - 7 points |
| 11/6/21 8:00 AM | 11/6/21 8:00 AM | Rot-Weiss Oberhausen | VfB Homberg | 3-1 | 5 - 7 points |
| 11/6/21 8:00 AM | 11/6/21 8:00 AM | KFC Uerdingen | Fortuna Düsseldorf II | 1-1 | 5 - 7 points |
| 11/6/21 8:00 AM | 11/6/21 8:00 AM | Sportfreunde Lotte | Rot-Weiss Ahlen | 4-1 | 5 - 7 points |
| 11/6/21 8:00 AM | 11/6/21 8:00 AM | FC Wegberg-Beeck | SV Rödinghausen | 1-1 | 5 - 7 points |
| 11/7/21 7:00 AM | 11/7/21 7:00 AM | Bonner SC | FC Schalke 04 II | 4-3 | 5 - 7 points |