Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | SG Wattenscheid 09 | Rot-Weiss Oberhausen | 1-1 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | SC Wiedenbrück | 1. FC Kaan-Marienborn | 1-2 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | Alemannia Aachen | SV Rödinghausen | 3-1 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | Rot-Weiss Ahlen | 1. FC Düren | 1-2 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | Bor. Mönchengladbach II | SV Lippstadt 08 | 4-2 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | 1. FC Bocholt | FC Schalke 04 II | 2-8 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | SV Straelen | 1. FC Köln II | 0-0 | 5 - 7 points |
| 11/5/22 8:00 AM | 11/5/22 8:00 AM | Wuppertaler SV | Fortuna Düsseldorf II | 4-1 | 5 - 7 points |
| 11/6/22 7:00 AM | 11/6/22 7:00 AM | SC Fortuna Köln | Preußen Münster | 1-3 | 5 - 7 points |