Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | Wuppertaler SV | Alemannia Aachen | 5-0 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | Preußen Münster | Rot-Weiss Oberhausen | 3-1 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | Rot-Weiss Ahlen | FC Wegberg-Beeck | 1-1 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | Rot-Weiss Essen | Sportfreunde Lotte | 3-1 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | SV Straelen | Bor. Mönchengladbach II | 1-0 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | SV Rödinghausen | Bonner SC | 1-0 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | FC Schalke 04 II | SV Lippstadt 08 | 2-1 | 5 - 7 points |
| 11/13/21 7:00 AM | 11/13/21 7:00 AM | VfB Homberg | KFC Uerdingen | 1-1 | 5 - 7 points |
| 12/8/21 12:30 PM | 12/8/21 12:30 PM | Fortuna Düsseldorf II | SC Wiedenbrück | 2-4 | 5 - 7 points |
| 12/8/21 12:30 PM | 12/8/21 12:30 PM | SC Fortuna Köln | 1. FC Köln II | 1-1 | 5 - 7 points |