Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/19/21 12:30 PM | 11/19/21 12:30 PM | FC Wegberg-Beeck | Rot-Weiss Essen | 1-1 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | KFC Uerdingen | Preußen Münster | 0-1 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | SC Wiedenbrück | VfB Homberg | 3-0 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | Bonner SC | SV Lippstadt 08 | 0-1 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | Alemannia Aachen | SC Fortuna Köln | 0-1 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | Rot-Weiss Oberhausen | FC Schalke 04 II | 4-0 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | Bor. Mönchengladbach II | Wuppertaler SV | 0-1 | 5 - 7 points |
| 11/20/21 7:00 AM | 11/20/21 7:00 AM | SV Rödinghausen | Rot-Weiss Ahlen | 0-1 | 5 - 7 points |
| 11/21/21 11:00 AM | 11/21/21 11:00 AM | Sportfreunde Lotte | SV Straelen | 1-2 | 5 - 7 points |
| 11/21/21 11:00 AM | 11/21/21 11:00 AM | 1. FC Köln II | Fortuna Düsseldorf II | 1-1 | 5 - 7 points |