Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/26/21 11:30 AM | 11/26/21 11:30 AM | Fortuna Düsseldorf II | Alemannia Aachen | 3-0 | 5 - 7 points |
| 11/26/21 12:00 PM | 11/26/21 12:00 PM | Preußen Münster | SC Wiedenbrück | 1-0 | 5 - 7 points |
| 11/26/21 12:30 PM | 11/26/21 12:30 PM | FC Schalke 04 II | KFC Uerdingen | 4-1 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | SV Straelen | FC Wegberg-Beeck | 0-0 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | VfB Homberg | 1. FC Köln II | 1-3 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | SC Fortuna Köln | Bor. Mönchengladbach II | 2-1 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | SV Lippstadt 08 | Rot-Weiss Oberhausen | 1-2 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | Bonner SC | Rot-Weiss Ahlen | 2-2 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | Rot-Weiss Essen | SV Rödinghausen | 1-0 | 5 - 7 points |
| 11/27/21 7:00 AM | 11/27/21 7:00 AM | Wuppertaler SV | Sportfreunde Lotte | 2-1 | 5 - 7 points |