Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/4/21 7:00 AM | 12/4/21 7:00 AM | SC Wiedenbrück | FC Schalke 04 II | 2-2 | 5 - 7 points |
| 12/4/21 7:00 AM | 12/4/21 7:00 AM | 1. FC Köln II | Preußen Münster | 1-1 | 5 - 7 points |
| 12/4/21 7:00 AM | 12/4/21 7:00 AM | SV Rödinghausen | SV Straelen | 3-0 | 5 - 7 points |
| 12/4/21 7:00 AM | 12/4/21 7:00 AM | KFC Uerdingen | SV Lippstadt 08 | 1-3 | 5 - 7 points |
| 12/4/21 7:00 AM | 12/4/21 7:00 AM | FC Wegberg-Beeck | Wuppertaler SV | 0-3 | 5 - 7 points |
| 12/4/21 7:00 AM | 12/4/21 7:00 AM | Rot-Weiss Oberhausen | Bonner SC | 3-1 | 5 - 7 points |
| 2/2/22 7:00 AM | 2/2/22 7:00 AM | Bor. Mönchengladbach II | Fortuna Düsseldorf II | 0-3 | 5 - 7 points |
| 2/15/22 11:30 AM | 2/15/22 11:30 AM | Sportfreunde Lotte | SC Fortuna Köln | 1-2 | 5 - 7 points |
| 2/16/22 12:30 PM | 2/16/22 12:30 PM | Alemannia Aachen | VfB Homberg | 2-0 | 5 - 7 points |
| 3/23/22 1:30 PM | 3/23/22 1:30 PM | Rot-Weiss Ahlen | Rot-Weiss Essen | 2-0 | 5 - 7 points |