Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/20/21 12:30 PM | 8/20/21 12:30 PM | Rot-Weiss Essen | SV Straelen | 1-4 | 5 - 7 points |
| 8/20/21 12:30 PM | 8/20/21 12:30 PM | 1. FC Köln II | SV Lippstadt 08 | 3-1 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | SV Rödinghausen | SC Fortuna Köln | 1-4 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | SC Wiedenbrück | Rot-Weiss Oberhausen | 1-0 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | KFC Uerdingen | Bonner SC | 1-3 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | Alemannia Aachen | FC Schalke 04 II | 1-1 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | Sportfreunde Lotte | VfB Homberg | 2-0 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | Rot-Weiss Ahlen | Wuppertaler SV | 0-0 | 5 - 7 points |
| 8/21/21 7:00 AM | 8/21/21 7:00 AM | FC Wegberg-Beeck | Fortuna Düsseldorf II | 1-2 | 5 - 7 points |
| 8/21/21 9:00 AM | 8/21/21 9:00 AM | Bor. Mönchengladbach II | Preußen Münster | 1-2 | 5 - 7 points |