Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/10/21 12:30 PM | 12/10/21 12:30 PM | Rot-Weiss Essen | Bonner SC | 6-1 | 5 - 7 points |
| 12/11/21 7:00 AM | 12/11/21 7:00 AM | Bor. Mönchengladbach II | VfB Homberg | 2-0 | 5 - 7 points |
| 12/11/21 7:00 AM | 12/11/21 7:00 AM | Alemannia Aachen | Preußen Münster | 0-2 | 5 - 7 points |
| 12/11/21 7:00 AM | 12/11/21 7:00 AM | SV Rödinghausen | Wuppertaler SV | 1-1 | 5 - 7 points |
| 12/11/21 7:00 AM | 12/11/21 7:00 AM | KFC Uerdingen | Rot-Weiss Oberhausen | 2-5 | 5 - 7 points |
| 12/11/21 7:00 AM | 12/11/21 7:00 AM | Rot-Weiss Ahlen | SV Straelen | 2-0 | 5 - 7 points |
| 12/13/21 7:00 AM | 12/13/21 7:00 AM | 1. FC Köln II | FC Schalke 04 II | 2-1 | 5 - 7 points |
| 12/14/21 11:30 AM | 12/14/21 11:30 AM | Sportfreunde Lotte | Fortuna Düsseldorf II | 3-1 | 5 - 7 points |
| 2/15/22 12:30 PM | 2/15/22 12:30 PM | SC Wiedenbrück | SV Lippstadt 08 | 2-2 | 5 - 7 points |
| 2/23/22 12:30 PM | 2/23/22 12:30 PM | FC Wegberg-Beeck | SC Fortuna Köln | 0-2 | 5 - 7 points |