Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/17/21 11:00 AM | 12/17/21 11:00 AM | SV Lippstadt 08 | 1. FC Köln II | 1-1 | 5 - 7 points |
| 12/17/21 12:00 PM | 12/17/21 12:00 PM | SC Fortuna Köln | SV Rödinghausen | 1-0 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | Rot-Weiss Oberhausen | SC Wiedenbrück | 1-2 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | Fortuna Düsseldorf II | FC Wegberg-Beeck | 1-3 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | SV Straelen | Rot-Weiss Essen | 0-1 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | Wuppertaler SV | Rot-Weiss Ahlen | 4-2 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | FC Schalke 04 II | Alemannia Aachen | 1-1 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | Bonner SC | KFC Uerdingen | 1-1 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | VfB Homberg | Sportfreunde Lotte | 1-2 | 5 - 7 points |
| 12/18/21 7:00 AM | 12/18/21 7:00 AM | Preußen Münster | Bor. Mönchengladbach II | 1-1 | 5 - 7 points |