Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 1/22/22 7:00 AM | 1/22/22 7:00 AM | Bor. Mönchengladbach II | FC Schalke 04 II | 1-4 | 5 - 7 points |
| 1/22/22 7:00 AM | 1/22/22 7:00 AM | Alemannia Aachen | SV Lippstadt 08 | 3-0 | 5 - 7 points |
| 1/22/22 7:00 AM | 1/22/22 7:00 AM | SV Straelen | Bonner SC | 0-0 | 5 - 7 points |
| 1/22/22 7:00 AM | 1/22/22 7:00 AM | SC Wiedenbrück | KFC Uerdingen | 5-1 | 5 - 7 points |
| 1/22/22 8:30 AM | 1/22/22 8:30 AM | 1. FC Köln II | Rot-Weiss Oberhausen | 1-0 | 5 - 7 points |
| 1/23/22 7:00 AM | 1/23/22 7:00 AM | Rot-Weiss Essen | Wuppertaler SV | 2-1 | 5 - 7 points |
| 3/2/22 12:30 PM | 3/2/22 12:30 PM | Sportfreunde Lotte | Preußen Münster | 2-3 | 5 - 7 points |
| 3/16/22 1:30 PM | 3/16/22 1:30 PM | SV Rödinghausen | Fortuna Düsseldorf II | 4-1 | 5 - 7 points |
| 3/16/22 1:30 PM | 3/16/22 1:30 PM | FC Wegberg-Beeck | VfB Homberg | 2-1 | 5 - 7 points |
| 3/30/22 12:30 PM | 3/30/22 12:30 PM | Rot-Weiss Ahlen | SC Fortuna Köln | 0-1 | 5 - 7 points |