Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 1/29/22 7:00 AM | 1/29/22 7:00 AM | Bonner SC | SC Wiedenbrück | 0-0 | 5 - 7 points |
| 1/29/22 7:00 AM | 1/29/22 7:00 AM | FC Schalke 04 II | Sportfreunde Lotte | 4-1 | 5 - 7 points |
| 1/29/22 7:00 AM | 1/29/22 7:00 AM | Preußen Münster | FC Wegberg-Beeck | 1-0 | 5 - 7 points |
| 1/29/22 7:00 AM | 1/29/22 7:00 AM | SV Lippstadt 08 | Bor. Mönchengladbach II | 0-1 | 5 - 7 points |
| 1/29/22 7:00 AM | 1/29/22 7:00 AM | KFC Uerdingen | 1. FC Köln II | 2-2 | 5 - 7 points |
| 2/15/22 12:30 PM | 2/15/22 12:30 PM | Fortuna Düsseldorf II | Rot-Weiss Ahlen | 1-1 | 5 - 7 points |
| 3/2/22 12:30 PM | 3/2/22 12:30 PM | VfB Homberg | SV Rödinghausen | 0-1 | 5 - 7 points |
| 3/9/22 12:00 PM | 3/9/22 12:00 PM | Wuppertaler SV | SV Straelen | 2-1 | 5 - 7 points |
| 3/16/22 1:30 PM | 3/16/22 1:30 PM | Rot-Weiss Oberhausen | Alemannia Aachen | 2-1 | 5 - 7 points |
| 3/16/22 1:45 PM | 3/16/22 1:45 PM | SC Fortuna Köln | Rot-Weiss Essen | 3-3 | 5 - 7 points |