Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/5/22 7:00 AM | 2/5/22 7:00 AM | Alemannia Aachen | KFC Uerdingen | 3-2 | 5 - 7 points |
| 2/5/22 7:00 AM | 2/5/22 7:00 AM | FC Wegberg-Beeck | FC Schalke 04 II | 1-4 | 5 - 7 points |
| 2/5/22 7:00 AM | 2/5/22 7:00 AM | 1. FC Köln II | SC Wiedenbrück | 0-0 | 5 - 7 points |
| 2/5/22 7:00 AM | 2/5/22 7:00 AM | SV Straelen | SC Fortuna Köln | 0-2 | 5 - 7 points |
| 2/5/22 7:00 AM | 2/5/22 7:00 AM | Rot-Weiss Ahlen | VfB Homberg | 3-3 | 5 - 7 points |
| 2/5/22 7:00 AM | 2/5/22 7:00 AM | Bor. Mönchengladbach II | Rot-Weiss Oberhausen | 0-3 | 5 - 7 points |
| 2/6/22 7:00 AM | 2/6/22 7:00 AM | Rot-Weiss Essen | Fortuna Düsseldorf II | 4-1 | 5 - 7 points |
| 2/23/22 12:30 PM | 2/23/22 12:30 PM | SV Rödinghausen | Preußen Münster | 1-0 | 5 - 7 points |
| 3/16/22 1:00 PM | 3/16/22 1:00 PM | Wuppertaler SV | Bonner SC | 0-3 | 5 - 7 points |
| 3/16/22 1:30 PM | 3/16/22 1:30 PM | Sportfreunde Lotte | SV Lippstadt 08 | 0-2 | 5 - 7 points |