Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/19/22 7:00 AM | 2/19/22 7:00 AM | FC Wegberg-Beeck | Rot-Weiss Oberhausen | 1-3 | 5 - 7 points |
| 2/19/22 7:00 AM | 2/19/22 7:00 AM | SV Straelen | VfB Homberg | 0-4 | 5 - 7 points |
| 2/19/22 7:00 AM | 2/19/22 7:00 AM | Bor. Mönchengladbach II | SC Wiedenbrück | 0-1 | 5 - 7 points |
| 2/20/22 7:00 AM | 2/20/22 7:00 AM | Rot-Weiss Essen | Preußen Münster | 0-2 | 5 - 7 points |
| 3/2/22 12:00 PM | 3/2/22 12:00 PM | SC Fortuna Köln | Bonner SC | 1-2 | 5 - 7 points |
| 3/30/22 12:30 PM | 3/30/22 12:30 PM | SV Rödinghausen | SV Lippstadt 08 | 2-1 | 5 - 7 points |
| 4/6/22 12:30 PM | 4/6/22 12:30 PM | Sportfreunde Lotte | KFC Uerdingen | 0-1 | 5 - 7 points |
| 4/13/22 11:00 AM | 4/13/22 11:00 AM | Wuppertaler SV | Fortuna Düsseldorf II | 0-2 | 5 - 7 points |
| 4/13/22 12:30 PM | 4/13/22 12:30 PM | Rot-Weiss Ahlen | FC Schalke 04 II | 3-2 | 5 - 7 points |
| 4/20/22 12:30 PM | 4/20/22 12:30 PM | Alemannia Aachen | 1. FC Köln II | 1-1 | 5 - 7 points |